Pharmacotherapeutic group: medicines used in erectile dysfunction. Tadalafil is a potent, selective, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). When sexual stimulation causes the local release of nitric oxide, inhibition of PDE5 by tadalafil produces increased levels of cGMP in the corpus cavernosum. This results in smooth muscle relaxation and inflow of blood into the penile tissues, thereby producing an erection. Tadalafil has no effect if there is no sexual stimulation.
Elimination:
The mean oral clearance for tadalafil is 2.5 L/hour and the mean half-life is 17.5 hours in healthy subjects. Tadalafil is excreted predominantly as inactive metabolites, mainly in the faeces (approximately 61% of the dose) and to a lesser extent in the urine (approximately 36% of the dose).
Use in Adult Men:
The recommended dose of (AGNUS-DS CAPSULE) is 20 mg, taken prior to anticipated sexual activity. The maximum recommended dosing frequency is once per day. (AGNUS-DS CAPSULE) may be taken between 30 minutes and 36 hours prior to anticipated sexual activity. Patients may initiate sexual activity at varying time points relative to dosing in order to determine their own optimal window of responsiveness. The dose may be lowered to 30 mg based on individual response and tolerability.(AGNUS-DS CAPSULE) may be taken without regard to food.
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